Abstract This work investigated the biochemical effects of methanol leaf extract of C. odorata on cypermethrin-induced oxidative stress on Wistar albino rats. C. odorata is used as a medicinal plant in a traditional way by the people who lived in the tropic and subtropic areas, for treatment of bloodsucker nibbles, soft tissue injuries, skin infections, malaria, and diabetes. A methodical quest for valuable bioactivities from medicinal plants is currently considered to be a rational methodology in nutraceutical and drug research. Manufactured pyrethroid, cypermethrin is utilized broadly for the management of bugs in crops and as an ectoparasiticide in man and creatures. For this work, cypermethrin was used to induce oxidative stress in wistar albino rats. The biochemical analyses were carried out following the standard procedures. The result obtained from the biochemical analysis shows that there is highest activity of catalase (1.60±0.20 U/mg protein) for the rats fed with cypermethrin when compared to group 1, fed with chromolena odorata (0.74±0.12U/mg protein) while comparing group 3 (1.09±0.23U/mg protein) and group 4 (0.92±0.13U/mg protein) which are statistically significant at P≤ 0.05 similar to SOD and MDA result. The effects of C. Odorata on cypermethrin-induced oxidative stress in Wistar albino rats on the biochemical parameters such as the Liver marker enzymes (ALT, AST, ALP), serum protein and kidney function (urea, creatinine levels) indicated that C. Odorata methanol leaf extract helped relieve stress in Wistar albino rats and furthermore, helped stabilize liver functions.
Keywords: Rats, Liver, Chromolaena, Methanol