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Abstract
The aim of this research work was to study the phytochemical and antibacterial activity of Gongronema latifolium extracts on clinical isolates. The phytochemical screening revealed the presence of the Flavonoids, Alkaloids, Tannins, Steroids, Glycosides and Saponins in the ethanol extract. Disc diffusion method was used to assay for the antimicrobial activity of the clinical isolates. The results of antibacterial activity based on the diameter of zone of inhibition, the results showed that the ethanol extract inhibited all the bacteria in varying range as Escherichia coli (14mm), Staphylococcus aureus (30mm), Streptococcus Sp. (15mm), Bacillus subtilis (14mm) and Salmonella Sp. (17mm) while fresh extract showed inhibition for Escherichia coli (14mm), Streptococcus Sp. (15mm), Bacillus subtilis (14mm) and Salmonella Sp. (17mm) as only Staphylococcus aureus resisted the fresh extract. In view of the above result, the traditional medicinal use of Gongronema latifolium leaf should be encouraged, since the ethanoic extracts and fresh extract of the leaves of these plant could be used to treating infection associated with the test bacteria hence, Pharmaceuticals can leverage on these finding towards formulating new drugs. Keyword: Antibacterial, Pathogens, Clinical, Inhibition, Gongronema latifolium